SDPsite: prediction of protein active and specific recognition sites from sequence and structure

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This family contains a protein with resolved 3D structure: RNP3_PYRHO/52-202, pdb ID: 1v77. SDPsite predicts following important positions (numbering corresponds to 1v77):

  • SDPs:

    131L, 83S, 80Y, 141E, 56A, 161V, 54K, 113D, 123K, 77Y, 173W, 68R, 109D, 126A, 140Y, 90R, 72Q, 116L, 116L, 137S, 191E, 103P, 153W, 119L, 190M, 89I, 121V, 138N, 74F, 99A, 94E, 172K, 160K, 108K, 85D

  • CPs:

    98D, 189G, 169A, 167S, 128G, 100I, 178P, 57I, 174D

  • Best cluster:

    80Y, 83S, 85D, 89I, 90R, 94E, 98D, 99A, 100I, 103P, 113D, 116L, 119L, 121V, 123K, 126A, 128G, 160K, 161V

  • Second best cluster:

    137S, 138N, 140Y, 141E

  • Mapping predictions onto structure of 1v77:

  • Associated grouping:

    • Group 1

      • RNP3_METJA/54-205
      • RNP3_ARCFU/29-174
      • RNP3_PYRHO/52-202
      • RNP3_PYRAB/52-203
    • Group 2

      • Q9TYZ2_CAEEL/145-296
      • RNP3_SCHPO/65-212
      • RPP1_YEAST/81-228
      • RP30_MOUSE/74-224
      • Q9VPM0_DROME/77-226